Ryuugamine Mikado is a boy who seeks for the exciting life of the big city--who yearns for an unmundane life; a hoodlum, a stalker denpa-girl, an informant, a champion fighter, a black-market doctor, and the Headless Rider astride a black motorcycle. But despite how different they are, all of these stories are interconnected by mysterious incidents going on in Ikebukuro: mysterious kidnappings, a pharmaceutical group supposedly performing human experiments, and the mysterious "colorless" gang known as the "Dollars." From then on, the existence of supernatural cases and a gang called the Yellow Turbans will rise to the surface, and Ikebukuro will pushed to the breaking point.